Biological Studies on Thiamine Related Compounds
نویسندگان
چکیده
منابع مشابه
The synthetic and biological studies of discorhabdins and related compounds.
Various analogues of the marine alkaloids, discorhabdins, have been synthesized. The strategy contains spirocyclization with phenyliodine(III) bis(trifluoroacetate) (PIFA), oxidative fragmentation of the β-amino alcohols with the hypervalent iodine reagent C(6)F(5)I(OCOCF(3))(2), the detosylation and dehydrogenation reaction of the pyrroloiminoquinone unit in the presence of a catalytic amount ...
متن کاملStudies on Thiamine Analocues
Several analogues of thiamine’ are known to compete with the vitamin when administered to animals. Thus, Woolley and White (1) have observed that pyrithiamine caused the manifestation of typical thiamine deficiency symptoms, which could be competitively overcome by the vitamin. The antivitamin effect of oxythiamine in mice has been reported by Soodak and Cerecedo (2). Cerecedo et al. (3, 4), co...
متن کاملStudies on Uric Acid and Related Compounds
The systematic study of the substrate specificity of mammalian xanthine oxidase has indicated a common mechanism by which various purines may be dehydrogenated (1). The results obtained also made it clear why methylated xanthines, with the exception of 1-methylxanthine (2), cannot be oxidized by xanthine oxidase to the corresponding substituted uric acids (3, 4). Therefore, another source had t...
متن کاملStudies on uric acid and related compounds. I. Quantitative determination of uric acid in biological fluids.
The available methods of determination of uric acid can be divided into three main groups: (a) the direct determination of the reducing power of uric acid; (b) the coprecipitation of the uric acid or its adsorption on a precipitating material, dissolving the acid, and determination of its reducing power; and (c) quantitative decomposition of uric acid by uricase. A survey of these methods has b...
متن کاملStudies on thiamine diphosphate-dependent enzymes.
The 3-deaza analogue of TPP (thiamine diphosphate), a close mimic of the ylid intermediate, has been synthesized and is an extremely potent inhibitor of a variety of TPP-dependent enzymes, binding much more tightly than TPP itself. Results using deazaTPP complexed with the E1 subunit of PDH (pyruvate dehydrogenase) have led to a novel proposal about the mechanism of this enzyme. The 2-substitut...
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ژورنال
عنوان ژورنال: The Japanese Journal of Nutrition and Dietetics
سال: 1961
ISSN: 1883-7921,0021-5147
DOI: 10.5264/eiyogakuzashi.19.174